Chronic kidney disease (CKD) is characterized by retention of a number of toxins, which unleash cellular damage. CKD environment ...

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Primary antiphospholipid antibody (APA) syndrome, a common prothrombotic disorder, has been known in dialysis patients and ...

Medical therapies are lacking for advanced renal cancer, so there is a great need to understand its pathogenesis. Most renal cancers ...

Local modulation of vascular mammalian target of rapamycin (mTOR) signaling reduces smooth muscle cell (SMC) proliferation ...

Autosomal-dominant polycystic kidney disease (ADPKD) and von Hippel-Lindau (VHL) disease lead to large kidney cysts that share ...

Although the influence of context-dependent endothelial cell (EC) regulation of vascular disease and repair is well-established, the ...

Old is gold and new is diamond! This is certainly not true for neointimal hyperplasia (NIH), in which blood vessels develop new ...

Skeletal muscles protect our internal organs, such as the kidneys, from physical injury. But protecting renal function in chronic kidney ...

Wnt signaling plays important roles in both the tumor-induced angiogenesis and tumorigenesis through the transcriptionally active...

Patients with CKD suffer high rates of thrombosis, particularly after endovascular interventions, yet few options are available to ...

“One size fits all” may be true in a number of situations, but not in the molecular machinery involved in chronic kidney disease (CKD) ...

Thrombotic complications of the nephrotic state occur with membranous nephropathy and to a lesser extent with minimal ...

A prospective cross-sectional study was performed on 170 patients with various glomerular diseases to study the accuracy of ...

The von Hippel-Lindau protein pVHL suppresses renal tumorigenesis in part by promoting the degradation of hypoxia-inducible ...

Cancer growth and metastasis are regulated in part by stromal cells such as fibroblasts and immune cells within the tumor ...

Stent thrombosis (ST), a postinterventional complication with a mortality rate of 50%, has an incidence that rises precipitously in ...

Activation of vascular endothelial growth factor receptor-2 (VEGFR-2), an endothelial cell receptor tyrosine kinase, promotes tumor ...

To most kids, the phrase “new jeans” means a trip to the mall. But for children with polyarteritis nodosa (PAN), “new genes” might mean ...

Compromised blood supply to a limb is usually compensated by the growth of collateral blood vessels in a process called ...

Oxidative damage to renal tubular epithelial cells is a fundamental pathogenic mechanism implicated in both acute kidney injury ...

Despite the loss of Adenomatous Polyposis Coli (APC) in a majority of colorectal cancers (CRC), not all CRCs bear hallmarks of Wnt ...

“Less is more” aptly applies to the effect of diet on longevity. Emerging evidence implicates several metabolites as influencing ...

To predict the risk of developing chronic renal failure in patients with primary focal glomerulosclerosis (FGS) using predictors ...

Peritoneal dialysis (PD) is a therapeutic option for acute renal failure (ARF) in developing countries, despite concerns about ...

Regulation of global chromatin acetylation is important for chromatin remodeling. A small family of Jade proteins includes Jade-1L, ...

Endothelial cells (ECs) embedded in 3D matrices [matrix-embedded endothelial cells (MEECs)] of denatured collagen implanted ...

Regulation of transcriptionally active nuclear β-catenin during the Wnt-on phase is crucial to ensure controlled induction ...

Fluid shear stresses are potent regulators of vascular homeostasis and powerful determinants of vascular disease progression ...

The saying that “tolerance fosters inner strength” is also true for the host’s immune response to infection. The host mounts ...

The pandemic of chronic kidney disease (CKD) has spurred intense interest in ways to retard the progression of renal failure ...

Expression and activation of vascular endothelial growth factor receptor 2 (VEGFR-2) by VEGF ligands are the main events in the ...