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Publications

2022 Publications

Derivation and Validation of a Clinical Risk Assessment Model for Cancer-Associated Thrombosis in Two ...

Venous thromboembolism (VTE), especially pulmonary embolism (PE) and lower extremity deep vein thrombosis (LE-DVT) ...

Pharmacologic Manipulation of Late SV40 Factor Suppresses Wnt Signaling and Inhibits ...

Aberrant hyperactivation of Wnt signaling, driven by nuclear β-catenin in the colonic epithelium, represents the seminal ...

Extracellular vimentin is an attachment factor that facilitates SARS-CoV-2 entry into human endothelial cells

Human angiotensin-converting enzyme 2 (ACE2) is the most widely known entry receptor for SARS-CoV-2. The possible involvement of ...

Understudied factors in drug-coated balloon design and evaluation: A biophysical perspective

Drug-coated balloon (DCB) percutaneous interventional therapy allows for durablereopening of the narrowed lumen ...

Janus Kinase Signaling Pathway and Its Role in COVID-19 Inflammatory, Vascular, and Thrombotic ...

Acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection continues to be a worldwide public health crisis ...

Tryptophan metabolites suppress the Wnt pathway and promote adverse limb events in chronic kidney disease

Chronic kidney disease (CKD) imposes a strong and independent risk for peripheral artery disease (PAD). While solutes retained in ...

A Retrograde Implantation Approach for Peritoneal Dialysis Catheter Placement in Mice

Murine models are employed to probe various aspects of peritoneal dialysis (PD), such as peritoneal inflammation and fibrosis. These ...

Intravenous sodium thiosulphate for vascular calcification of hemodialysis patients - a systematic review ...

Vascular calcification (VC) is a common comorbidity among patients with chronic kidney disease (CKD), indicating major ...

2021 Publications

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SARS-CoV-2 Disrupts Proximal Elements in the JAK-STAT Pathway

SARS-CoV-2 can infect multiple organs, including lung, intestine, kidney, heart, liver, and brain. The molecular details of how ...

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End-stage kidney disease and COVID-19 in an urban safety-net hospital in Boston, Massachusetts

End-stage kidney disease (ESKD) patients are at a high risk for Coronavirus Disease 2019 (COVID-19). In this study, we compared ...

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Transmembrane and Immunoglobulin Domain Containing 1, a Putative Tumor Suppressor, Induces G2/M...

Colorectal cancer (CRC) is a leading nonfamilial cause of cancer mortality among men and women. Although various...

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CD209L/L-SIGN and CD209/DC-SIGN Act as Receptors for SARS-CoV-2

As the COVID-19 pandemic continues to spread, investigating the processes underlying the interactions between SARS-CoV-2...

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Bibliometric Analysis of Machine Learning Applications in Nephrology

Artificial intelligence driven by machine learning algorithms is being increasingly employed for early detection, disease ...

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Tryptophan metabolites suppress the Wnt pathway and promote adverse limb events in chronic kidney disease

Chronic kidney disease (CKD) imposes a strong and independent risk for peripheral artery disease (PAD). While solutes...

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Deep-Learning Driven Quantification of Interstitial Fibrosis in Digitized Kidney Biopsies

Interstitial fibrosis and tubular atrophy (IFTA) on a renal biopsy are strong indicators of disease chronicity and prognosis. Techniques...

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Uraemic solutes as therapeutic targets in CKD-associated cardiovascular disease

Chronic kidney disease (CKD) is characterized by the retention of a myriad of solutes termed uraemic (or uremic) toxins, which ...

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Indoleamine 2,3-dioxygenase-1, a novel therapeutic target in thrombotic uremic toxicity

Background CKD, characterized by retained uremic solutes, is a strong and independent risk factor for thrombosis after vascular ...

2020 Publications

A painful lesson from the COVID-19 pandemic: the need for broad-spectrum, host-directed antivirals

While the COVID-19 pandemic has spurred intense research and collaborative discovery worldwide, the development...

Platelet Dysfunction and Thrombosis in JAK2 V617F-Mutated Primary Myelofibrotic Mice

The risk of thrombosis in myeloproliferative neoplasms, such as primary myelofibrosis varies depending on the...

Haploinsufficiency of Casitas B-Lineage Lymphoma Augments the Progression of Colon Cancer in the Background ...

Casitas B-lineage lymphoma (c-Cbl) is a recently identified ubiquitin ligase of nuclear β-catenin and a suppressor of colorectal...

Hyperthrombotic Milieu in COVID-19 Patients

COVID-19 infection has protean systemic manifestations. Experience from previous coronavirus outbreaks, including...

Loss of MINAR2 impairs motor function and causes Parkinson’s disease-like symptoms in mice

Parkinson’s disease is the second most common human neurodegenerative disease. Motor control impairment represents...

Black Patients Experience Highest Rates of Cancer associated Venous Thromboembolism

Cancer patients are at a higher risk of venous thromboembolism (VTE) than the general population. In the general population ...

Molecular Mechanisms Underlying the Cardiovascular Toxicity of Specific Uremic Solutes

Mounting evidence strongly suggests a causal link between chronic kidney disease (CKD) and cardiovascular disease...

Temporal and tissue-specific activation of aryl hydrocarbon receptor in discrete mouse models of kidney...

Emerging evidence in animal models of chronic kidney disease (CKD) implicates Aryl Hydrocarbon Receptor (AHR) signaling as a ...

2019 Publications

Metabolites in a mouse cancer model enhance venous thrombogenicity through the aryl hydrocarbon ...

Patients with malignancy are at 4- to 7-fold higher risk of venous thromboembolism (VTE), a potentially fatal, yet preventable ...

Novel lysyl oxidase inhibitors attenuate hallmarks of primary myelofibrosis in mice

Primary myelofibrosis (PMF) is a chronic myeloproliferative neoplasm (MPN) that usually portends a poor prognosis with limited ...

Unique aspects of peripheral artery disease in patients with chronic kidney disease

Peripheral artery disease (PAD) represents a major health care burden. Despite the advent of screening and interventional procedures ...

Segmentation of Glomeruli Within Trichrome Images Using Deep Learning

The number of glomeruli and glomerulosclerosis evaluated on kidney biopsy slides constitute standard components of a renal pathology...

c-Cbl targets PD-1 in immune cells for proteasomal degradation and modulates colorectal tumor growth

Casitas B lymphoma (c-Cbl) is an E3 ubiquitin ligase and a negative regulator of colorectal cancer (CRC). Despite its high expression ...

Emerging Factors Implicated in Fibrotic Organ-Associated Thrombosis: The Case of Two Organs

Thrombosis is at the heart of cardiovascular complications observed in specific diseases. A heightened thrombosis risk above ...

Monoclonal IgG4/2κ Deposition Following Eculizumab Therapy for Recurrent Atypical Hemolytic ...

Eculizumab is an emerging therapy for atypical hemolytic uremic syndrome (aHUS). Early identification and treatment of recurrent ...

Intrinsic coating morphology modulates acute drug transfer in drug-coated balloon therapy

The hallmark of drug-coated balloon (DCB) therapy for the treatment of peripheral vascular disease is that it allows for reopening of the ...

Determinants of Hemodialysis Performance:Modeling Fluid and Solute Transport in Hollow-Fiber ...

Hemodialysis constitutes the lifeline of patients with end stage renal disease, yet the parameters that affect hemodialyzer ...

c-Cbl: An Important Regulator and a Target in Angiogenesis and Tumorigenesis

Casitas B lineage lymphoma (c-Cbl) is a multifunctional protein with a ubiquitin E3 ligase activity capable of degrading diverse ...

Towards minimally-invasive, quantitative assessment of chronic kidney disease using optical spectroscopy

The universal pathologic features implicated in the progression of chronic kidney disease (CKD) are interstitial fibrosis and tubular ....

2018 Publications

Association of Pathological Fibrosis With Renal Survival Using Deep Neural Networks

Chronic kidney damage is routinely assessed semiquantitatively by scoring the amount of fibrosis and tubular atrophy in a renal biopsy ...

Uremic Solute-Aryl Hydrocarbon Receptor-Tissue Factor Axis Associates with Thrombosis after Vascular ...

Individuals with CKD are particularly predisposed to thrombosis after vascular injury. Using mouse models, we recently described ....

c-Cbl Expression Correlates with Human Colorectal Cancer Survival and Its Wnt/β-Catenin ...

The proto-oncogene β-catenin drives colorectal cancer (CRC) tumorigenesis. Casitas B-lineage lymphoma (c-Cbl) inhibits CRC tumor ...

Hepatitis C virus infection in kidney transplantation-changing paradigms with ...

Hepatitis C virus (HCV) is a common cause of increased morbidity and mortality in kidney transplant patients. It is associated with ...

2017 Publications

Matrix-Embedded Endothelial Cells Attain a Progenitor-Like Phenotype

Culture of endothelial cells (ECs) embedded in 3D scaffolds of denatured collagen has shown tremendous therapeutic potential ...

Upregulation of lysyl oxidase and adhesion to collagen of human megakaryocytes and platelets in ...

Primary myelofibrosis (PMF) is characterized by the presence of bone marrow fibrosis associated with increased abundance of ...

Racial differences in colorectal cancer survival in a safety net hospital

While racial disparity in colorectal cancer survival have previously been studied, whether this disparity exists in patients with ...

Concurrent Presentation of Thrombotic Thrombocytopenic Purpura and Membranous Nephropathy

Acquired thrombotic thrombocytopenic purpura (TTP) is a hematologic emergency associated with decreased thrombospondin ...

Thrombotic Microangiopathy: A Multidisciplinary Team Approach

Thrombotic microangiopathy (TMA) is characterized by the presence of microangiopathic hemolytic anemia and ...

Targeting STUB1-tissue factor axis normalizes hyperthrombotic uremic phenotype without increasing ...

Chronic kidney disease (CKD/uremia) remains vexing because it increases the risk of atherothrombosis and is also associated with ...

Targeting tumor multicellular aggregation through IGPR-1 inhibits colon cancer growth and ...

Adhesion to extracellular matrix (ECM) is crucially important for survival of normal epithelial cells as detachment ...

A mass spectrometric method for quantification of tryptophan-derived uremic solutes in human serum

In addition to various physiologic roles, emerging evidence strongly points to pathogenic roles of tryptophan and of its ...

2016 and Earlier

Thrombosis in the uremic milieu--emerging role of "thrombolome"

Chronic kidney disease (CKD) is characterized by retention of a number of toxins, which unleash cellular damage. CKD environment ...

Dyslipidemia in chronic renal failure patients

Acute renal failure in a renal transplant donor due to primary antiphospholipid syndrome

Primary antiphospholipid antibody (APA) syndrome, a common prothrombotic disorder, has been known in dialysis patients and ...

Jade-1, a candidate renal tumor suppressor that promotes apoptosis

Medical therapies are lacking for advanced renal cancer, so there is a great need to understand its pathogenesis. Most renal cancers ...

Smooth muscle cells orchestrate the endothelial cell response to flow and injury

Local modulation of vascular mammalian target of rapamycin (mTOR) signaling reduces smooth muscle cell (SMC) proliferation ...

Polycystin-1 regulates the stability and ubiquitination of transcription factor Jade-1

Autosomal-dominant polycystic kidney disease (ADPKD) and von Hippel-Lindau (VHL) disease lead to large kidney cysts that share ...

Dysfunctional endothelial cells directly stimulate cancer inflammation and metastasis

Although the influence of context-dependent endothelial cell (EC) regulation of vascular disease and repair is well-established, the ...

Keeping the Flow Going: FGFR1 Protects Vascular Patency by Inhibiting Occlusive Neointimal Hyperplasia

Old is gold and new is diamond! This is certainly not true for neointimal hyperplasia (NIH), in which blood vessels develop new ...

Muscles Protect the Kidneys

Skeletal muscles protect our internal organs, such as the kidneys, from physical injury. But protecting renal function in chronic kidney ...

The c-Cbl ubiquitin ligase regulates nuclear β-catenin and angiogenesis by its tyrosine ...

Wnt signaling plays important roles in both the tumor-induced angiogenesis and tumorigenesis through the transcriptionally active...

The Aryl Hydrocarbon Receptor is a Critical Regulator of Tissue Factor Stability and an Antithrombotic ...

Patients with CKD suffer high rates of thrombosis, particularly after endovascular interventions, yet few options are available to ...

Angiotensin Blockade—A Double-Edged Sword in Renal Failure

“One size fits all” may be true in a number of situations, but not in the molecular machinery involved in chronic kidney disease (CKD) ...

Minimal change nephrosis and antiphospholipid antibodies: coincidental or associated?

Thrombotic complications of the nephrotic state occur with membranous nephropathy and to a lesser extent with minimal ...

Cost-benefit analysis and prediction of 24-hour proteinuria from the spot urine protein-creatinine ratio

A prospective cross-sectional study was performed on 170 patients with various glomerular diseases to study the accuracy of ...

Jade-1 inhibits Wnt signalling by ubiquitylating beta-catenin and mediates Wnt pathway inhibition ...

The von Hippel-Lindau protein pVHL suppresses renal tumorigenesis in part by promoting the degradation of hypoxia-inducible ...

Stromal endothelial cells directly influence cancer progression

Cancer growth and metastasis are regulated in part by stromal cells such as fibroblasts and immune cells within the tumor ...

Uremic serum and solutes increase post-vascular interventional thrombotic risk through altered ...

Stent thrombosis (ST), a postinterventional complication with a mortality rate of 50%, has an incidence that rises precipitously in ...

Lysine methylation promotes VEGFR-2 activation and angiogenesis

Activation of vascular endothelial growth factor receptor-2 (VEGFR-2), an endothelial cell receptor tyrosine kinase, promotes tumor ...

Inflammatory Web Catches Vessels

To most kids, the phrase “new jeans” means a trip to the mall. But for children with polyarteritis nodosa (PAN), “new genes” might mean ...

A Tug of War in the Periphery

Compromised blood supply to a limb is usually compensated by the growth of collateral blood vessels in a process called ...

TMIGD1 is a novel adhesion molecule that protects epithelial cells from oxidative cell injury

Oxidative damage to renal tubular epithelial cells is a fundamental pathogenic mechanism implicated in both acute kidney injury ...

c-Cbl mediates the degradation of tumorigenic nuclear β-catenin contributing to the heterogeneity in ...

Despite the loss of Adenomatous Polyposis Coli (APC) in a majority of colorectal cancers (CRC), not all CRCs bear hallmarks of Wnt ...

α-Ketoglutarate-A New Currency of Longevity

“Less is more” aptly applies to the effect of diet on longevity. Emerging evidence implicates several metabolites as influencing ...

Predicting renal survival in primary focal glomerulosclerosis from the time of presentation

To predict the risk of developing chronic renal failure in patients with primary focal glomerulosclerosis (FGS) using predictors ...

Is peritoneal dialysis adequate for hypercatabolic acute renal failure in developing countries?

Peritoneal dialysis (PD) is a therapeutic option for acute renal failure (ARF) in developing countries, despite concerns about ...

Role of Jade-1 in the histone acetyltransferase (HAT) HBO1 complex

Regulation of global chromatin acetylation is important for chromatin remodeling. A small family of Jade proteins includes Jade-1L, ...

Matrix-embedded endothelial cells are protected from the uremic milieu

Endothelial cells (ECs) embedded in 3D matrices [matrix-embedded endothelial cells (MEECs)] of denatured collagen implanted ...

c-Cbl, a ubiquitin E3 ligase that targets active β-catenin: a novel layer of Wnt signaling regulation

Regulation of transcriptionally active nuclear β-catenin during the Wnt-on phase is crucial to ensure controlled induction ...

Loss of syndecan-1 induces a pro-inflammatory phenotype in endothelial cells with a dysregulated ...

Fluid shear stresses are potent regulators of vascular homeostasis and powerful determinants of vascular disease progression ...

AHR: A Temple of Tolerance to Toxemia

The saying that “tolerance fosters inner strength” is also true for the host’s immune response to infection. The host mounts ...

Good-in-good-out: Diet modification in chronic kidney disease

The pandemic of chronic kidney disease (CKD) has spurred intense interest in ways to retard the progression of renal failure ...

Hypoxia-induced expression of phosducin-like 3 regulates expression of VEGFR-2 and ...

Expression and activation of vascular endothelial growth factor receptor 2 (VEGFR-2) by VEGF ligands are the main events in the ...

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